Mitglieder

Mitglieder der GBM Studiengruppe RNA-Biochemie

Alexander Dalpke
www.klinikum.uni-heidelberg.de/Dalpke-lab
Immunostimulatory properties of RNA / Effects of RNA modifications on immune sensing
Organism(s): Vertebrates and bacteria
Keywords: Immunostimulation , Innate Immunity , Toll-like receptors , RNA modifications

Sven Diederichs
www.dkfz.de/en/molekulare-rna-biologie/index.php
www.uniklinik-freiburg.de/cancer-research.html
RNA Biology & Cancer
Organism(s): Homo sapiens
Keywords: Non-coding RNA, Non-coding mutations, Cancer

Utz Fischer
www.biochem.biozentrum.uni-wuerzburg.de
RNA biology and human diseases // Structure and function of RNPs
Organism(s): Eucaryotic cells, zebrafish, vaccinia virus
Keywords: Functional biochemistry, macrololecular crystallography, CLIP, RNA metabolism and neuronal diseases

Mark Helm
www.ak-helm.pharmazie.uni-mainz.de
RNA modification // therapeutic RNA
Organism(s): any and all
Keywords: posttranscriptional modification, modified RNA, LC-MS, RNA-Seq (analysis, Illumina), nanoparticles, siRNA formulation

Stephanie Kath-Schorr (YI)
www.sks-lab.uni-bonn.de
Functional RNA
Organism(s):
Keywords: RNA labeling, Click chemistry, Unnatural base pairs, nucleoside synthesis, nucleic acid synthesis, Ribozymes, RNA modifications

Rene Ketting
www.imb.de/research/ketting/research/
Mechanisms and functions of small RNAs in germ cells
Organism(s): Caenorhabditis elegans, zebrafish
Keywords: piRNA,siRNA,RNA-Seq (analysis, Illumina), Argonaute
protein, germ cell, genetics, transposon

Dagmar Klostermeier
www.uni-muenster.de/Chemie.pc/klostermeier/group.html
Mechanisms of molecular machines
Organism(s): E. coli, B. subtilis, T. thermophilus, T. maritima, Saccharomyces cerevisiae
Keywords: RNA helicases, unwinding, mechanism, regulation, conformational dynamics, single molecule FRET,  DNA topoisomerases

Jens Kurreck
www.angewbiochem.tu-berlin.de/menue/home/
Medical applications of RNA technologies
Organism(s): human
Keywords: RNA interference, CRISPR/Cas, RNA G-quadruplexes, AAV vectors, organ models, 3D printing

Markus Landthaler
www.mdc-berlin.de/landthalerlab
RNA-binding proteins and RNA biology
Organism(s): mammalian cell culture systems
Keywords: CLIP-seq, RNA-seq, ribo-seq, mRNA interactome capture

Marcus Lechner (YI)
http://www.lechnerlab.de
Comparative genomics and evolution
Organism(s): Bacteria, Aquifex aeolicus, Bacillus subtilis, Enterococcus, LAB
Keywords: bioinformatics, comparative genomics, orthology, RNA-Seq, ICLIP, ncRNAs, 6S RNA, RNase P

Sebastian Leidel (YI)
http://www.mpi-muenster.mpg.de/22088/leidel
RNA modification and translational control
Organism(s): Saccharomyces cerevisiae, Danio rerio, Saccharomyces paradoxus, Candida albicans, human and murine stem cells
Keywords: Ribosome profiling, RNA-Seq, RNA mass spectrometry, Northern blot and CRISPR-Cas9 mediated gene editing

Patrick A Limbach
www.bearcatms.uc.edu/
Improved mass spectrometric methods to characterize modified ribonucleic
acids (RNAs) and ribonucleoprotein complexes (RNPs) / nucleic acid analysis by mass
spectrometry, structural biology and medical applications.
Organism(s): Eukaryotes, Prokaryotes and Archaea
Keywords: Post transcriptional modifications, transfer ribonucleic acid,
modification mass mapping, mass spectrometry

Alexandra Lusser
www.i-med.ac.at/molbio/Research/Group-Lusser
Posttranscriptional modification of mRNA and lncRNA
Organism(s): Mouse, human, Drosophila melanogaster
Keywords: RNA cytosine methylation, RNA-seq (Illumina, IonTorrent), bisulfite sequencing, methyl-immunoprecipitation (MeRIP), immunonorthern blotting, in vitro binding assays, cell culture methods, embryonic stem cells, Drosophila genetics

Anita Marchfelder
www.uni-ulm.de/nawi/nawi-molbot/research/anita-marchfelder/
Ribonucleases, small regulatory RNAs and CRISPR-Cas in Archaea
Organism(s): Haloarchaea, Haloferax volcanii, Halorubrum lacusprofundi
Keywords: Type I CRISPR-Cas, RNA processing, CRISPRi

Mario Mörl
www.biochemie.biphaps.uni-leipzig.de/arbeitsgruppen/biochemie-und-molekularbiologie/
tRNA Nucleotidyltransferases / Synthetic Riboswitches
Organism(s): Escherichia coli, Bacillus subtilis, psychrophilic bacteria, thermophilic bacteria
Keywords: enzyme evolution, riboswitch design, tRNA-Seq (Illumina), RNA structure probing (in-line probing, enzymatic probing)

Wolfgang Nellen
www.http://www.sciencebridge.net/

Dierk Niessing
www.helmholtz-muenchen.de/stb/niessing
mRNA localization and translational control in eukaryotes
Organism(s): Saccharomyces cerevisiae, mouse human
Keywords: X-ray crystallography, RNA biochemistry, quantitative interaction studies, chemical probing of RNAs

Lennart Randau
www.mpi-marburg.mpg.de/randau
Regulatory RNA and CRISPR-Cas in archaea, Minimal Type I CRISPR-Cas systems in proteobacteria
Organism(s): Hyperthermophilic archaea, Sulfolobus acidocaldarius, Shewanella putrefaciens, Proteobacteria
Keywords: RNase footprinting, RNA-Seq (analysis, Illumina),
Type I CRISPR-Cas

Christian Schmitz-Linneweber
https://www.molgen.hu-berlin.de/
Organelle gene expression, RNA degradation, RNA editing; RNA-protein interactions, helical hairpin repeat proteins
Organism(s): Plants (Arabidopsis thaliana; Nicotiana tabacum); Apicomplexans (Plasmodium falciparum; Toxoplasma gondii)
Keywords: organellar RNA metabolism, acclimation of RNA processing in plants, RIP-Seq; RNA Bind-N-Seq; CRISPR-Cas in Arabidopsis; chloroplast transformation

Cynthia Sharma
www.imib-wuerzburg.de/research/sharma/research/
Regulatory RNAs and RNA binding proteins in pathogenic Epsilonproteobacteria
Organism(s): Epsilonproteobacteria, Helicobacter pylori, Campylobacter jejuni
Keywords: Small regulatory RNAs (sRNAs), RNA binding proteins (RBPs), RNA-Protein complexes (RNPs), CRISPR-Cas, bacterial pathogens, infection biology, RNA modifications, RNA Biology, RNA-Seq, Ribo-Seq, RNA structure probing

Alexander Wolf (YI)
www.helmholtz-muenchen.de/en/toxi/research/research-fields-research-units/epigenetics/research/
Epigenetics
Keywords: posttranscriptional regulation of gene expression, splicing, RNA modifications, translation